Marijuana Tolerance: When Is the Time to Take a Tolerance Break?

Do me a quick favor. Close your eyes and try to remember how it felt when you got high for the very first time.

Remember the strong buzz in your head and that fuzzy, warm feeling spreading through your entire body. What about the legs, can you remember not feeling them at some point?

Yeah, when you smoke weed for a while, you get to a point where smoking joint after joint does not make you nearly as high as that first puff did. Unfortunately, the majority of experienced cannabis users develop marijuana tolerance at some point.

It all starts off nice and simple. Rookies and occasional users don’t need much weed to get high, as they get stoned with just a few puffs. However, as people start smoking more frequently, they quickly notice how their tolerance bar rises and, suddenly, they need more to achieve the same effects.

If you can recognize yourself in the paragraph above, know that you are not alone in this. Cannabis tolerance is common and inevitable, but it can be fixed.

In this article, we’ll explore what exactly causes marijuana tolerance, how to overcome it and how to take a tolerance break without breaking a sweat.

What is marijuana tolerance?

What is marijuana tolerance

Scientifically said, marijuana tolerance is the brain’s adaptation to the constant presence of cannabinoids, in which higher doses of marijuana are needed to obtain the effect of the first dose.

In other words, developing tolerance means that after some time of consuming cannabis you become a bit resistant to it and need increasingly larger amounts to get high.

Tolerance builds up with many substances, not just with cannabis. Coffee is one of them.

Tolerance to certain substances happens because of a neurological phenomenon called downregulation.

As you expose your system to one substance, the number of receptors in the brain that react to that particular substance reduces over time because your body strives to maintain the system balance and prevent an overload in any way, shape or form. As soon as this process starts, we need more of the substance to feel the same effects as we once did.

THC, a psychoactive compound in cannabis and one of the most abundant cannabinoids, produces effects by attaching itself to two groups of cellular receptors, CB1 and CB2.

Therefore, the downregulation of CB1 and CB2 (cannabinoid receptors type 1 and 2) leads to developing cannabis tolerance.

One very recent study confirmed that marijuana tolerance is real. The group of researchers did an experiment with male participants aged between 18 and 35. They focused on CB1 receptors, for which THC has considerable binding affinity.

Besides proving what we’ve already suspected, they also found something very interesting: regular (but moderate) daily cannabis users had 20% less CB1 receptors than the participants from the control group who did not use cannabis. (1)

And how long does it take to regenerate CB1 receptors?

Well, believe it or not, it takes just two days to four weeks of abstinence to regenerate almost all of your CB receptors. What was really surprising in this study is that no matter how much cannabis they consumed, after just a two-day tolerance break, test subjects started growing their CB1 receptors back. (1)

This study was criticized for not including female participants, since THC supposedly affects women differently, but we can all agree that this is a good starting point for further research.

But besides sex, there are many other factors that affect how people build up tolerance to cannabis. Both the consumption method and the amount consumed play a major role in developing tolerance, as do some physiological factors like the body mass index for example.

The truth is that the human body actually becomes tolerant to cannabis very quickly.

It takes just one week of frequent cannabis use to build enough tolerance to start needing an increased amount for the same results. The situation gets even worse when you realize that smoking high THC strains leads to developing tolerance faster. (2)

Interestingly enough, it seems that some parts of our body develop tolerance very quickly, while some don’t develop it at all. Colon, for example, seems to be resistant to marijuana tolerance. (3)

Can marijuana tolerance be avoided?

Avoid tolerance

It can. There are a few things that you can do to avoid building up tolerance to cannabis.

This problem primarily happens with heavy daily consumers to begin with. So, the first thing you can do for yourself is to reduce the frequency and volume of cannabis consumption to a moderate level.

The trick to this is to use an approach called microdosing, which relies on using the smallest amounts of cannabis you need to achieve the desired effects. This approach is particularly useful for medical users who need to stay medicated throughout the day.

To do this properly, take just a few puffs at a time, and don’t smoke the whole joint by yourself. By following this routine you will not be completely resistant to developing tolerance, but you will not build it up as quickly as if you were to smoke an ounce a day all by yourself.

When to take a marijuana tolerance break?

When you reach the point where almost no amount of cannabis can get you high enough, it’s time to take a break and rebuild your receptors.

The easiest way to do so is to abstain from cannabis for 1-2 weeks. The more you abstain the better your results will be, but a week should be the absolute minimum if you’d like to do it the right way.

Taking a tolerance break is actually not that difficult, as you’ll be motivated by the fact that your receptors will grow back fully. Best of all, the first joint you light up after that week will feel like you’re getting high for the first time, once again.

Although it can be tough to stay away from weed, especially when the anxiety kicks in, give it your best and try to stay on the right path. Trust me, it’s worth it.

Here are a few tricks that I use whenever I take tolerance break.

First, make a plan and use the free time to work on yourself. Keep yourself busy, stay active and try to workout. Go back to some of your old hobbies (if you had them) and try to eat healthier.

Put away all your smoking gear. Pipes, bongs and rolling papers should be out of your sight during the break.

Get rid of your weed. No, really — don’t stash it for when the break is over. It’s always tempting when you know you have some in the bottom drawer.

Surround yourself with people you love, go out more to social gatherings and events. All in all, do the things that really make you happy (except smoking weed, yikes).

How to bring down cannabis tolerance without taking a break?

Bring down tolerance

For some people, taking a tolerance break is not fun at all. It’s particularly hard if you are a medical user. Anxiety, sleepless nights and mood changes are just a few side effects of taking a weed tolerance break.

However, there are a few methods to lower your tolerance to some extent without quitting weed completely.

Change your routine

Although us humans are addicted to routines, switching it all up from time to time can be very beneficial. And I suppose you already have a routine when it comes to smoking weed.

However, your body will eventually get used to all those cannabinoids at the same exact time and that will aid in boosting your tolerance up.

By introducing a few changes in your daily routine, you’re shocking your body and you’re not letting it get used to cannabis. To start, try consuming weed at different times than usual. That can actually trick your brain into thinking you are doing something new.

Don’t wake and bake

When you get stoned in the morning you have to smoke all day to maintain the same level of high. And that’s not good if you are trying to lower your tolerance. So, we go back to the first advice: try smoking later in the evening to shock your body a little bit.

Limit the amount of cannabis you consume

It’s simple. More weed leads to developing tolerance faster. So if you’ve already reached a point where you need more and more to get high, you might want to go down the opposite route and start smoking less. I talked about microdosing earlier in this article, but if that doesn’t do the trick for you, cut the amount of weed you smoke in half.

That way, your system will quickly get used to less THC, and when you go back to your usual routine, you’ll feel the difference, along with that potent high you’ve been waiting for.

Also, try cutting down the number of daily smoke sessions.

Use smaller rolling papers

Smaller papers, smaller joints, less weed. This is a good starting point and the easiest way to cut the amount of weed you are smoking without having to quit completely.

King size joints build up your tolerance quickly. So, switch to smaller ones.

Change your method of consumption

Besides smoking, you can vape or make edibles. Dabbing will definitely knock you out of your shoes since the concentrates are much more potent than regular flowers.

Edibles are a great alternative to smoking if you’re looking to switch this up as well. In fact, eating a brownie infused with cannabutter can actually get you really high.

Smoking gets cannabinoids into your body in just a few minutes, but the effects don’t last as long as with edibles.

Since the digestion process takes much more time, it will take about 45 minutes to feel the effects of weed. But once THC starts to kick in, the high is much stronger — and lasts for hours.

Try out different strains

There are thousands of strains out there, with different THC to CBD ratios and different terpene profiles. Try something new and different. Check out strains with different potencies and explore what your budtender has to offer you.

Switch to CBD

If you are working on lowering your marijuana tolerance maybe it’s time to try some truly amazing CBD strains. Although CBD diminishes the psychoactive effects of THC, you will not feel that buzz in your head as you normally would.

Take supplements

If you are a medical user, taking a tolerance break might be a no-go. But keep in mind that there are other natural remedies and supplements. Even though cannabis might be a natural remedy for many conditions, there are other plant-based alternatives that can get you through your tolerance break.

Valerian root is a mild natural remedy for insomnia and anxiety. Lavender oil capsules also reduce anxiety and help you take the edge off and get through the day.

Omega-3 fatty acids help the endocannabinoid system function properly. According to a study conducted by the Neurocentre Magendie in Bordeaux, France, a lack of dietary Omega-3 fatty acids leads to inhibited function of the CB1 receptors, which may result in mood swings and impaired emotional behaviour. (4)

To put this into our perspective, if you don’t consume enough Omega-3’s, you get poor performing CB1 receptors and the entire functioning of your endocannabinoid system is in jeopardy. This means you automatically need more weed to get high.

Stock up on Omega 3’s by eating fish, nuts and seeds (like chia). Alternatively, you can always supplement with Omega-3’s, but just make sure you find a reputable brand.

Enhance the high with mango

This is a very simple stoner trick — take a few slices of mango about 30 to 45 minutes before you smoke weed.

Mango is full of myrcene, a terpene that is also found in almost every marijuana strain. Eating a mango before smoking will help THC break the blood-brain barrier faster.


  • Marijuana tolerance is very common among stoners and largely depends on the frequency and volume of use.
  • Tolerance develops when you oversensitize CB receptors from excess cannabis, which then reduce in numbers.
  • If you start noticing that you need increasingly more weed to get high, it’s time to take a tolerance break.
  • To regenerate your receptors back and rebuild your tolerance, abstain from weed from 1-4 weeks.


  1. D’Souza DC, Cortes-Briones JA, Ranganathan M, Thurnauer H, Creatura G, Surti T, Planeta B, Neumeister A, Pittman B, Normandin M, Kapinos M, Ropchan J, Huang Y, Carson RE, Skosnik PD; Rapid Changes in CB1 Receptor Availability in Cannabis Dependent Males after Abstinence from Cannabis; Biological Psychiatry. Cognitive Neuroscience and Neuroimaging; January 2016; 1(1):60-67
  2. Maldonado R; Study of cannabinoid dependence in animals; Pharmacology and Therapeutics; August 2002; 95(2):153-64
  3. Sim-Selley LJ; Regulation of cannabinoid CB1 receptors in the central nervous system by chronic cannabinoids; Critical Review in Neurobiology; 2003;15(2):91-119
  4. Lafourcade M, Larrieu T, Mato S, Duffaud A, Sepers M, Matias I, De Smedt-Peyrusse V, Labrousse VF, Bretillon L, Matute C, Rodríguez-Puertas R, Layé S, Manzoni OJ; Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions; Nature Neuroscience; March 2011; 14(3):345-50
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In charge of Greencamp’s health section, with a decade-long experience of using cannabis for stress relief. Her spare time is mostly divided between dancing, traveling and reading.

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